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Toshihiro Akisue Selected Research

Malignant Fibrous Histiocytoma

9/2015Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS.
8/2014Transcutaneous application of CO2 enhances the antitumor effect of radiation therapy in human malignant fibrous histiocytoma.
1/2012Transcutaneous application of carbon dioxide (CO2) induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo.
12/2011Inhibition of induced autophagy increases apoptosis of Nara-H cells.
11/2011Protein kinase Cδ in tumorigenesis of human malignant fibrous histiocytoma.
9/2010The effect of bevacizumab on tumour growth of malignant fibrous histiocytoma in an animal model.
1/2007Imatinib mesylate inhibits tumorigenicity of malignant fibrous histiocytoma cells in vivo.
9/2004Expression of transforming growth factor beta isoforms and their receptors in malignant fibrous histiocytoma of soft tissues.
9/2004Inhibitory effect of STI571 on cell proliferation of human malignant fibrous histiocytoma cell lines.
5/2004Expression of betacellulin, heparin-binding epidermal growth factor and epiregulin in human malignant fibrous histiocytoma.
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Toshihiro Akisue Research Topics

Disease

33Neoplasms (Cancer)
06/2022 - 01/2002
15Malignant Fibrous Histiocytoma
09/2015 - 05/2003
11Neoplasm Metastasis (Metastasis)
06/2022 - 07/2007
10Osteosarcoma (Osteogenic Sarcoma)
06/2022 - 01/2002
6Sarcoma (Soft Tissue Sarcoma)
01/2022 - 11/2002
3Pain (Aches)
04/2021 - 04/2003
3Clear Cell Sarcoma
12/2020 - 03/2013
3Contracture
01/2020 - 08/2019
3Fibrosis (Cirrhosis)
01/2020 - 08/2019
3Squamous Cell Carcinoma of Head and Neck
07/2018 - 01/2014
3Osteolysis
03/2004 - 03/2002
2Giant Cell Tumor of Bone
09/2022 - 08/2018
2Breast Neoplasms (Breast Cancer)
11/2021 - 10/2018
2Bone Resorption
01/2021 - 02/2002
2Osteoporosis
01/2021 - 02/2002
2Spinal Cord Injuries (Spinal Cord Injury)
10/2019 - 08/2019
2Hyperglycemia
05/2019 - 03/2019
2Hypoxia (Hypoxemia)
10/2018 - 08/2013
2Body Weight (Weight, Body)
01/2017 - 09/2010
2Neurilemmoma (Schwannoma)
09/2015 - 11/2011
1Soft Tissue Neoplasms
01/2022
1Necrosis
11/2021
1Synovial Sarcoma (Synovioma)
03/2021
1Shock
01/2021
1Heart Diseases (Heart Disease)
09/2020
1Muscular Atrophy (Muscle Atrophy)
10/2019
1Disease Progression
07/2019
1Fibrosarcoma
10/2018
1Developmental Dysplasia of the Hip
09/2018
1Normal Pressure Hydrocephalus
01/2018
1Osteomyelitis
01/2017
1Infections
01/2017

Drug/Important Bio-Agent (IBA)

11Carbon DioxideIBA
09/2020 - 01/2012
8Proteins (Proteins, Gene)FDA Link
11/2021 - 06/2003
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2019 - 11/2006
5Messenger RNA (mRNA)IBA
09/2015 - 05/2003
4Protein Isoforms (Isoforms)IBA
06/2012 - 09/2003
3Stem Cell FactorIBA
02/2005 - 05/2003
2DenosumabFDA Link
09/2022 - 08/2018
2Phenylalanine (L-Phenylalanine)FDA Link
01/2022 - 12/2015
2Collagen Type I (Type I Collagen)IBA
01/2020 - 08/2019
2Transforming Growth Factor beta (TGF-beta)IBA
08/2019 - 09/2004
2Streptozocin (Streptozotocin)FDA Link
05/2019 - 03/2019
2Small Interfering RNA (siRNA)IBA
09/2015 - 11/2011
2Caspase 3 (Caspase-3)IBA
03/2014 - 01/2012
2Imatinib Mesylate (Gleevec)FDA Link
01/2007 - 09/2004
2Epidermal Growth Factor (EGF)IBA
05/2004 - 03/2004
2LigandsIBA
03/2004 - 05/2003
1Essential Amino AcidsIBA
01/2022
1Amino Acid Transport Systems (Amino Acid Transporter)IBA
01/2022
1Biomarkers (Surrogate Marker)IBA
11/2021
1MicroRNAs (MicroRNA)IBA
11/2021
1Parathyroid Hormone-Related ProteinIBA
11/2021
1Estrogens (Estrogen)FDA Link
01/2021
1salicylhydroxamic acid (SHAM)IBA
01/2021
1Keratins (Keratin)IBA
12/2020
1OsteocalcinIBA
10/2020
1CollagenIBA
01/2020
1Botulinum Toxins (Botulinum Toxin)IBA
10/2019
1GemcitabineFDA Link
07/2019
1Docetaxel (Taxotere)FDA Link
07/2019
1Nitric Oxide (Nitrogen Monoxide)FDA Link
05/2019
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
05/2019
1Thrombospondin 1IBA
03/2019
1Tartrate-Resistant Acid PhosphataseIBA
10/2018
1Hematoxylin (Haematoxylon)IBA
10/2018
1Oxygen (Dioxygen)IBA
10/2018
1Eosine Yellowish-(YS) (Eosin)IBA
10/2018
1Doxorubicin (Adriamycin)FDA LinkGeneric
11/2017
1N- benzhydryl- 5- (2- (methylamino)propanamido)- 3- (3- methylbutanoyl)- 6- oxodecahydropyrrolo(1,2- a)(1,5)diazocine- 8- carboxamideIBA
11/2017
1HydrogelsIBA
06/2017
1Anti-Bacterial Agents (Antibiotics)IBA
01/2017
1Clindamycin (Cleocin)FDA LinkGeneric
01/2017
1Panton-Valentine leukocidinIBA
01/2017
1Linezolid (Zyvox)FDA Link
01/2017
1VancomycinFDA LinkGeneric
01/2017
1AICA ribonucleotide (ZMP)IBA
01/2017
1VimentinIBA
04/2016
1Cadherins (E-Cadherin)IBA
04/2016

Therapy/Procedure

12Therapeutics
09/2022 - 12/2011
5Drug Therapy (Chemotherapy)
06/2022 - 06/2012
5Arthroplasty
09/2018 - 02/2002
4Boron Neutron Capture Therapy
01/2022 - 03/2013
3Curettage
09/2022 - 08/2018
2Myotomy
10/2019 - 08/2019
2Radiotherapy
07/2018 - 08/2014
2Replantation
11/2002 - 01/2002
1Operative Surgical Procedures
04/2021
1Activities of Daily Living (ADL)
04/2021
1Ovariectomy (Oophorectomy)
01/2021
1Stem Cell Transplantation
05/2020
1Metastasectomy
01/2020
1Injections
10/2019
1Anesthesia
10/2019
1Physical Therapy Modalities (Physical Therapy Technique)
08/2019
1Combination Drug Therapy (Combination Chemotherapy)
07/2019
1Disarticulation
10/2018
1Cerebrospinal Fluid Shunts
01/2018
1Palliative Care (Palliative Therapy)
01/2017
1Aftercare (After-Treatment)
01/2017